In zootomy and dermatology, skin is an organ of the integumentary system composed of a layer of tissues that protect underlying muscles and organs. As the interface with the surroundings, it plays the most important role in protecting against pathogens. Its other main functions are insulation and temperature regulation, sensation and vitamin D and B synthesis. Mammalian skin often contains hairs, which in sufficient density is called fur. The hair mainly serves to augment the insulation the skin provides, but can also serve as a secondary sexual characteristic or as camouflage. On some animals the skin is very hard and thick, and can be processed to create leather. Reptiles and fish have hard protective scales on their skin for protection, and birds have hard feathers, all made of tough β-keratins. Amphibian skin is not a strong barrier to passage of chemicals. A frog sitting in an anesthetic solution will quickly go to sleep. The skin is often known as "the largest organ in the human body". This applies to exterior surface, as it covers the body, appearing to have the largest surface area of all the organs. Moreover, it applies to weight, as it weighs more than any single internal organ, accounting for about 15 percent of body weight. For the average adult human, the skin has a surface area of between 1.5-2.0 square metres, most of it is between 2-3 mm thick. The average square inch of skin holds 650 sweat glands, 20 blood vessels, 1000 melanocytes, and more than a thousand nerve endings. Skin is composed of the epidermis and the dermis. Below these layers lies the hypodermis(subcutaneous adipose layer), which is not usually classified as a layer of skin. Functions of the skin are disturbed when it is dirty and it becomes more easily damaged. The release of antibacterial compounds decreases. Dirty skin is more prone to develop infections. Cosmetics should be used carefully because these may cause allergic reactions. Each season requires suitable clothing in order to facilitate the evaporation of the sweat. Sunlight, water and air play an important role in keeping the skin healthy. The skin supports its own ecosystems of microorganisms, including yeasts and bacteria, which cannot be removed by any amount of cleaning. In general these organisms keep one another in check and are part of a healthy skin. When the balance is disturbed, e.g., by antibiotics which kill bacteria, there may be an overgrowth and infection by yeasts. The skin is continuous with the inner epithelial lining of the body at the orifices, each of which supports its own complement of flora.
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